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Addition of LGI1 test, related to epileptic ADLTE

 

Tests for mutations of the LGI1 gene have been established. Mutations in the LGI1 (Leucine-rich, glioma inactivated 1) gene results in an epileptic phenotype with autosomal dominant lateral temporal epilepsy (ADLTE) characterized by auditory auras and focal seizures. The test provided is a screen of all exons and exon-intron boundaries. Thus the test allows the analysis of all familial known mutations and a test of any new mutation in a previously not characterized family.