Electrical Status Epilepticus during Sleep (ESES) is part of our Childhood Epilepsy Panel (NGS). Click here to access a complete list of the genes covered in this panel. 



ESES is an age-related pileptic encephalopathy (EE) with very low incidence, typically in individuals between a few months of age and 12 years, peaking around ages 4-5. 


In ESES, there is a disorder in the epileptiform activity in the brain that takes place during sleep, causing "unseen" (subclinical) seizures, although clinical seizures can also occur. Seizures can be of a varied typology (clonic, tonic-clonic, absences, partial, unilateral...). The first seizures are infrequent, and in many cases, unilateral. These seizures go on to increase in terms of frequency and intensity within the next 1 or 2 years after onset, producing some form of neurocognitive regression. 


Although this condition tends to resolve with time, there can be sequelae in neuropsychological development (language capacity, intellectual level, memory, behavior) as well as motor impairment. Therefore, treatment (both aimed to control the seizures and the epileptiform activity) is necessary to diminish the consequences.


The treatment is aimed to control the seizures, but also its cause, the epileptiform activity.


All of Amplexa's neurology tests can be found in our Neurology Brochure