autosomal dominant nocturnal frontal lobe epilepsy (adnfle)

ADNFLE is part of our Childhood Epilepsy Panel (NGS). Click here to access a complete list of the genes covered in this panel. 




ADNFLE is a rare form of inherited epilepsy. This disorder causes nocturnal seizures while the affected person is sleeping, although some people might experience these during the day. ADNFLE usually begins in childhood, it might appear later.


Seizures usually occur in clusters, often preceded by an aura (perceptual disturbances). Duration and severity are variable; lasting from a few seconds to a few minutes, and ranging from very mild seizures to more aggressive ones which include motor disorders (repetitive movements, getting out of bed, etc.) Seizures tend to moderate with age, becoming milder and less frequent. While no developmental sequelae is observed, some psychiatric or behavioral disorders have been potentially related to patients with ADNFLE.


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